FETAL DNA (NIPT) TEST IN İZMİR

Safe, Accurate, and Non-Invasive Prenatal Genetic Screening

What Is the NIPT Test?

NIPT (Non-Invasive Prenatal Testing) — also known as the Fetal DNA test or cell-free fetal DNA (cffDNA) test — is a highly advanced screening method that provides early and accurate information about your baby’s genetic health through a simple blood sample from the mother. This modern test can detect the most common chromosomal abnormalities without posing any risk to either the mother or the baby.

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In İzmir, NIPT testing is offered at several modern hospitals, IVF centers, and specialized genetic laboratories equipped with cutting-edge sequencing technologies. Because it only requires a blood sample from the mother’s arm, the test is completely safe, unlike invasive procedures such as amniocentesis or chorionic villus sampling (CVS).

How Does the NIPT Test Work?

During pregnancy, fragments of your baby’s DNA — known as cell-free fetal DNA — circulate in your bloodstream. From the 10th week of pregnancy, these fragments can be isolated and analyzed using advanced genetic sequencing methods such as Next Generation Sequencing (NGS).

In İzmir’s certified genetic laboratories, this technology allows specialists to examine the number and structure of chromosomes to detect extra or missing ones, which may indicate genetic conditions such as Down, Edwards, or Patau syndromes.

Results are usually available within 7–10 days, and some laboratories in İzmir also offer express results within 3–5 days.

What Conditions Can NIPT Detect?

Major Chromosomal Abnormalities

NIPT is designed to detect the most common genetic abnormalities with extremely high accuracy:

Down Syndrome (Trisomy 21): Caused by an extra copy of chromosome 21; detection accuracy above 99%.
Edwards Syndrome (Trisomy 18): Caused by an extra chromosome 18; detection rate around 97%.
Patau Syndrome (Trisomy 13): Caused by an extra chromosome 13; detection rate above 90%.

Sex Chromosome Abnormalities

In addition to trisomies, NIPT can also identify conditions related to sex chromosomes, such as:

Turner Syndrome (45,X)
Klinefelter Syndrome (47,XXY)
Triple X Syndrome (47,XXX)
Jacobs Syndrome (47,XYY)

Extended Genetic Panels

Several genetic centers in İzmir also offer expanded NIPT panels that include testing for rare genetic conditions such as DiGeorge, Prader-Willi, and Angelman syndromes. Your doctor can advise you on whether extended genetic analysis is suitable for your pregnancy.

When Should the NIPT Test Be Performed?

The 10th week of pregnancy is the ideal time to perform NIPT, as there is sufficient fetal DNA circulating in the mother’s blood for accurate results. The test can also be done later in pregnancy, including the second and third trimesters, without affecting accuracy.

Who Should Consider NIPT?

Although NIPT is suitable for all pregnant women, it is particularly recommended for those who:

Are aged 35 years or older
Have abnormal first-trimester screening test results
Conceived through IVF or assisted reproduction
Have a family history of chromosomal disorders
Have ultrasound findings suggesting possible genetic risk
Want to avoid invasive diagnostic tests like amniocentesis
Are carriers of balanced chromosomal translocations

Advantages of the NIPT Test

Highly Accurate: Detects Down syndrome and other trisomies with over 99% reliability.
Completely Safe: Requires only a blood sample from the mother; no risk to the baby.
Early Detection: Can be performed as early as 10 weeks of pregnancy.
Determines Gender: Identifies baby’s gender accurately if requested.
Fewer False Positives: Minimizes the need for invasive tests.
Fast and Convenient: Simple, painless, and requires no fasting or preparation.

Limitations of the NIPT Test

Although NIPT is extremely reliable, it is a screening test, not a diagnostic test:

A positive (high-risk) result does not confirm a diagnosis; it indicates increased likelihood. Confirmatory tests such as amniocentesis or CVS are required.
NIPT does not detect all genetic or structural disorders, such as single-gene mutations or neural tube defects.
In rare cases, results may be inconclusive if the fetal DNA fraction is too low. Retesting after 1–2 weeks usually provides a result.
The accuracy may be slightly lower in twin pregnancies compared to single pregnancies.

How Is the NIPT Test Performed?

Before the Test:
Your obstetrician or genetic counselor will explain the procedure, what conditions the test screens for, and how to interpret the results. İzmir’s leading clinics often provide genetic counseling before and after testing.

During the Test:
A small blood sample is drawn from your arm. The procedure is quick, safe, and does not require fasting.

After the Test:
The blood sample is sent to an accredited genetic laboratory. Results are typically available in 7–10 business days. Your doctor will interpret the findings and guide you on the next steps if necessary.

Understanding the Results

Low-Risk (Negative):
Indicates a very low likelihood of the screened chromosomal abnormalities. Regular prenatal care continues.

High-Risk (Positive):
Indicates an increased probability of a chromosomal condition. Diagnostic confirmation with amniocentesis or CVS is recommended.

Inconclusive Result:
In rare cases, the test may fail to provide a result due to insufficient fetal DNA. Repeating the test after a short interval often solves the issue.

NIPT Test Cost in İzmir

Basic NIPT tests: 12,500 – 14,000 TL
Extended panels: 15,000 – 18,000 TL

Prices vary depending on the laboratory, the type of panel selected, and the turnaround time. Some centers offer faster results for an additional cost.

Insurance Coverage:
The NIPT test is not covered by Turkey’s Social Security Institution (SGK). However, some private insurance providers may cover part of the cost.

Where to Get the NIPT Test in İzmir

You can take the NIPT test in İzmir at:

Private hospitals and obstetrics clinics
Genetic diagnostic laboratories such as İzmir Genetik or EgeLab
IVF centers and perinatology departments that offer prenatal genetic testing

These facilities use internationally approved testing standards and experienced specialists to ensure accuracy and reliability.

Comparison with Other Prenatal Tests

Traditional Screening Tests (Double and Triple Test):
These tests are less accurate and have higher false-positive rates compared to NIPT.

Ultrasound (Nuchal Translucency Measurement):
Ultrasound remains vital for monitoring the baby’s anatomy and growth. NIPT complements ultrasound but does not replace it.

Frequently Asked Questions

Is NIPT mandatory?
No, it is an optional screening test that provides additional reassurance.

Can NIPT determine the baby’s gender?
Yes, gender determination is possible from week 10 onward if requested.

Does NIPT replace amniocentesis?
No, NIPT is a screening test. A positive result requires confirmation through diagnostic testing.

Is fasting required?
No, fasting or preparation is not necessary.

Can twins be tested?
Yes, though accuracy may be slightly lower than in single pregnancies.

When are results available?
Usually within 7–10 days; express options may deliver results in 3–5 days.

Final Thoughts

The Fetal DNA (NIPT) Test in İzmir provides expectant parents with peace of mind through early, safe, and precise prenatal genetic screening. With advanced laboratories, expert gynecologists, and comprehensive counseling, İzmir is one of Turkey’s leading centers for modern prenatal care.

By combining NIPT with regular ultrasound follow-ups and healthy lifestyle habits, families can ensure a safe and informed pregnancy experience.