FETAL DNA (NIPT) TEST IN ISTANBUL

Safe, Accurate, and Non-Invasive Prenatal Screening

What Is the NIPT Test?

NIPT (Non-Invasive Prenatal Testing), also known as the Fetal DNA test or cell-free fetal DNA (cffDNA) test, is a modern prenatal screening method that provides reliable information about your baby’s genetic health. By analyzing small fragments of fetal DNA circulating in the mother’s bloodstream, the test can detect common chromosomal abnormalities early in pregnancy — safely and accurately.

For information and appointments: +90 542 225 89 12 – Ataşehir / Istanbul

In Istanbul, NIPT testing is performed in specialized hospitals, private clinics, and advanced genetic laboratories equipped with international-level technology. Unlike traditional prenatal tests that may involve risks or discomfort, NIPT requires only a blood sample from the mother’s arm. It poses no risk to the mother or baby, offering peace of mind for expecting families.

How Does the NIPT Test Work?

During pregnancy, fragments of the baby’s DNA from the placenta enter the mother’s bloodstream. These are called cell-free fetal DNA (cffDNA). As early as the 10th week of pregnancy, there is enough fetal DNA in the maternal blood to allow for accurate genetic analysis.

In Istanbul’s advanced genetic laboratories, these DNA fragments are analyzed using Next Generation Sequencing (NGS) technology. This powerful method examines the number and structure of chromosomes to detect potential abnormalities. The test can also determine the baby’s gender, if requested.

Results are usually ready within 7–10 days, and some laboratories in Istanbul offer express options that deliver results in 3–5 days.

Conditions Detected by NIPT

Common Chromosomal Abnormalities

NIPT testing identifies the most frequent chromosomal disorders with very high accuracy:

Down Syndrome (Trisomy 21): The most common chromosomal disorder caused by an extra copy of chromosome 21. Detection rate: over 99%.
Edwards Syndrome (Trisomy 18): A serious condition caused by an extra 18th chromosome. Detection rate: about 97%.
Patau Syndrome (Trisomy 13): Caused by an extra 13th chromosome. Detection accuracy: above 90%.

Sex Chromosome Abnormalities

In addition to these conditions, NIPT can detect imbalances in sex chromosomes:

Turner Syndrome (45,X)
Klinefelter Syndrome (47,XXY)
Triple X (47,XXX)
Jacobs Syndrome (47,XYY)

Extended Genetic Panels

Some genetic centers in Istanbul offer expanded NIPT panels that can identify additional chromosomal conditions and rare microdeletion and microduplication syndromes. These include conditions such as DiGeorge, Prader-Willi, and Angelman syndromes. It’s best to discuss with your doctor whether an extended panel is necessary based on your medical history and family background.

When Can the NIPT Test Be Done?

The NIPT test can be performed from the 10th week of pregnancy onward. This is when fetal DNA in the maternal bloodstream reaches a sufficient level for accurate analysis.

Many clinics and hospitals in Istanbul recommend performing NIPT between the 10th and 20th weeks of pregnancy. However, the test can also be done later in pregnancy without any risk to mother or baby.

Who Should Consider NIPT?

Although NIPT can be offered to all pregnant women, it is especially recommended for:

Women aged 35 years or older
Those with abnormal results from combined or triple screening tests
Pregnancies with family history of genetic disorders
IVF (in vitro fertilization) pregnancies
Women who wish to avoid invasive procedures like amniocentesis or CVS
Expectant mothers who have had previous pregnancies affected by chromosomal abnormalities
Parents carrying balanced chromosomal rearrangements

Advantages of the NIPT Test

1. High Accuracy
NIPT offers a detection rate of over 99% for Down syndrome and more than 95% for other trisomies, making it one of the most accurate prenatal screening tools available today.

2. Completely Safe
Because it uses only maternal blood, there is no risk of miscarriage or harm to the baby.

3. Early Results
It can be performed as early as the 10th week, providing valuable information early in pregnancy.

4. Gender Determination
NIPT can accurately determine the baby’s gender earlier than an ultrasound.

5. Fewer False Positives
Compared to traditional screening tests, NIPT dramatically reduces the likelihood of false positives, minimizing unnecessary stress and procedures.

6. Simple and Painless
No fasting or special preparation is required. The test only involves a standard blood draw.

Limitations of NIPT

While NIPT is an excellent screening tool, it is not a diagnostic test. A “high-risk” or “positive” result does not confirm a diagnosis — it only indicates an increased likelihood. Confirmatory testing such as amniocentesis or chorionic villus sampling (CVS) is required for final diagnosis.

Also, NIPT does not detect all genetic disorders. It primarily screens for chromosomal number abnormalities, but it cannot identify single-gene disorders or structural malformations.

In rare cases, the test may not produce results due to insufficient fetal DNA in the blood sample. This can happen more often in early pregnancies or in women with higher body mass. If this occurs, the test can usually be repeated after 1–2 weeks.

How Is the NIPT Test Performed?

Before the Test:
Your obstetrician will explain the procedure, its purpose, and what the results might indicate. Many Istanbul clinics offer genetic counseling sessions to help you understand your options.

During the Test:
A healthcare professional will draw a small blood sample from your arm. No fasting or special preparation is necessary.

After the Test:
The sample is sent to an accredited laboratory for analysis. Results are usually available within 7–10 business days, depending on the laboratory’s workload.

Understanding the Results

Low Risk (Negative) Result:
A low-risk result means that your baby is unlikely to have any of the tested chromosomal abnormalities. Routine pregnancy care can continue as planned.

High Risk (Positive) Result:
A high-risk result means there is a greater chance of a chromosomal abnormality, but it is not definitive. Your doctor may recommend diagnostic confirmation through amniocentesis or CVS.

Inconclusive Result:
If fetal DNA in the blood sample is insufficient, the test may be inconclusive. Most clinics in Istanbul offer a repeat test free of charge or at a reduced cost.

NIPT Test Cost in Istanbul

Basic NIPT tests: 12,500 – 14,000 TL
Extended panels: 15,000 – 18,000 TL

Prices may vary slightly depending on the laboratory, hospital, and the scope of the test. Some premium medical centers in Istanbul may charge more for faster turnaround times or additional genetic screening options.

Insurance coverage:
The NIPT test is currently not covered by the Turkish Social Security Institution (SGK). However, some private insurance policies may cover the test under specific conditions.

Where to Get the NIPT Test in Istanbul

NIPT testing is widely available in:

University hospitals with genetics departments
Private maternity hospitals and clinics
Specialized genetic diagnostic centers

These facilities follow international standards, using advanced sequencing technology to ensure accurate and reliable results.

Comparison with Other Prenatal Tests

Traditional Double and Triple Tests:
These screening tests remain common but have lower accuracy and higher false-positive rates compared to NIPT.

Ultrasound Examination:
Ultrasound, especially nuchal translucency (NT) measurement, remains crucial for assessing the baby’s anatomy and growth. It is often used together with NIPT for comprehensive prenatal evaluation.

NIPT and ultrasound complement each other — they are not substitutes.

Frequently Asked Questions

Is NIPT mandatory?
No, it is an optional screening test chosen by the parents.

Can the NIPT test determine the baby’s gender?
Yes, with nearly 100% accuracy as early as 10 weeks.

Does NIPT replace amniocentesis?
No. NIPT is a screening test; amniocentesis is still required to confirm high-risk results.

Is fasting required before the test?
No, fasting is not needed.

Can twins be tested?
Yes, NIPT can be performed in twin pregnancies, though accuracy is slightly lower than in single pregnancies.

How long does it take to receive results?
Most laboratories deliver results within 7–10 days. Some clinics offer express results in 3–5 days.

Final Thoughts

The Fetal DNA (NIPT) Test in Istanbul is one of the safest and most advanced methods for evaluating your baby’s genetic health. With no risk to the mother or fetus, NIPT offers accurate, early, and comprehensive insights — all through a simple blood test.

Istanbul’s state-of-the-art medical infrastructure, experienced obstetricians, and accredited genetic laboratories make it a trusted destination for prenatal care.

Regular follow-up appointments, detailed ultrasounds, and open communication with your doctor remain essential for ensuring a healthy pregnancy. NIPT serves as a vital part of modern prenatal care, combining safety with scientific precision.