FETAL DNA (NIPT) TEST IN KADIKÖY

Safe & Accurate Prenatal Genetic Screening

What Is the NIPT Test?

NIPT (Non-Invasive Prenatal Testing), also referred to as a fetal DNA test or cell-free fetal DNA (cffDNA) test, is a modern prenatal screening procedure that analyzes fragments of your baby’s DNA circulating in your bloodstream. It provides early, reliable insight into potential chromosomal abnormalities and supports informed decision-making during pregnancy.

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In Kadıköy, the test is conducted at specialized clinics, obstetrics centres and genetic laboratories equipped with advanced technology. Unlike invasive methods, NIPT requires only a maternal blood sample—posing no risk to mother or baby.

How Does the NIPT Test Work?

During pregnancy, small fragments of fetal DNA from the placenta enter the mother’s bloodstream. These are known as cell-free fetal DNA (cffDNA). From about the 10th week of pregnancy onward, the amount of fetal DNA in maternal blood is sufficient to allow for accurate analysis.

In Kadıköy’s dedicated genetic laboratories, the sample is processed using Next Generation Sequencing (NGS) technology, enabling detailed assessment of chromosome number and structure. The analysis may also provide early determination of fetal sex if desired.

Results are typically available within 7–10 days, and express processing (sometimes 3–5 days) may also be offered.

Conditions That Can Be Detected

Major Chromosomal Abnormalities

NIPT primarily screens for three key trisomies with very high detection rates:

Down Syndrome (Trisomy 21): Caused by an extra copy of chromosome 21; detection rate >99%.
Edwards Syndrome (Trisomy 18): Extra copy of chromosome 18; detection rate ~97%.
Patau Syndrome (Trisomy 13): Extra copy of chromosome 13; detection rate >90%.

Sex Chromosome Variations

The test also assesses imbalances in sex chromosomes, including:

Turner Syndrome (45,X)
Klinefelter Syndrome (47,XXY)
Triple X (47,XXX)
Jacobs Syndrome (47,XYY)

Expanded Panels

Some centres in Kadıköy offer extended NIPT panels that detect rarer abnormalities such as microdeletions and microduplications, including syndromes like DiGeorge, Prader-Willi, and Angelman. Your obstetrician can advise whether the extended panel is appropriate in your case.

When Should the NIPT Be Performed?

The ideal time for NIPT is from the 10th week of pregnancy onward, when fetal DNA levels in the maternal blood are adequate. While earlier testing may not yield sufficient DNA, the test remains safe and valid throughout the second and even third trimesters.

Who Should Consider NIPT?

Although available to all pregnant women, NIPT is particularly recommended in cases such as:

Maternal age 35 years or older
High-risk result from first-trimester combined screening
Family history of chromosomal abnormalities
Ultrasound findings suggestive of genetic risk
IVF or other assisted reproduction pregnancies
Parents carrying balanced chromosomal rearrangements
Desire to avoid invasive procedures such as amniocentesis or CVS

Advantages of the NIPT Test

High accuracy: Superior detection rates compared to traditional screening.
Completely safe: Only requires maternal blood—no risk to baby or mother.
Early timing: Can be done as early as 10 weeks.
Gender determination: If requested, fetal sex can be identified with high reliability.
Reduces unnecessary invasive tests: Lowers false-positive rates and hence decreased need for further invasive diagnostics.
Simple and convenient: No fasting, minimal preparation, quick procedure.

Limitations of the NIPT Test

Screening, not diagnostic: A high‐risk result is not a definitive diagnosis—confirmatory diagnostic testing (amniocentesis or CVS) is still required.
Not all conditions covered: Single-gene disorders, structural chromosome abnormalities, and neural tube defects may not be detected.
Possible inconclusive result: Rarely, insufficient fetal DNA in the maternal sample may yield an inconclusive result—more likely if done very early or if maternal BMI is high. Retesting may be offered.
Twins/multiple pregnancies: For twin pregnancies, NIPT is possible but accuracy is slightly reduced; for triplets or higher, recommendations may differ.

How the Test Is Performed

Before the Test:
Your obstetrician or genetic counsellor will discuss the test rationale, possibility of findings, implications and next steps. Many centres in Kadıköy include pre‐test genetic counselling.

During the Test:
A standard blood sample is drawn from the mother’s arm. No special preparation or fasting is required.

After the Test:
The sample is sent to an accredited genetic laboratory for sequencing and analysis. Results are communicated to your clinician who will review them with you.

Interpreting the Results

Low Risk (Negative) Result:
Indicates a low probability of the tested chromosomal abnormalities. Routine prenatal care continues. Note: does not guarantee a completely unaffected baby.

High Risk (Positive) Result:
Indicates increased probability of a chromosomal abnormality; diagnostic testing (amniocentesis or CVS) is recommended for definitive diagnosis.

Inconclusive Result:
Insufficient fetal DNA in the sample—repeat testing often resolves the issue. Many centres provide free or discounted retesting.

Cost of the NIPT Test in Kadıköy

Basic NIPT tests: 12,500 – 14,000 TL
Extended genetic panels: 15,000 – 18,000 TL

Insurance coverage: This test is currently not covered by the national Social Security Institution (SGK). Some private health insurance plans may cover some or all of the cost depending on the policy.

Where to Access NIPT in Kadıköy

NIPT is available in:

Private obstetrics and gynecology clinics
Specialized genetic diagnostic centres
University hospital genetics departments

Such facilities in Kadıköy follow international quality standards and utilize advanced sequencing technologies to ensure accuracy and reliability.

Comparison with Other Prenatal Screenings

First‐trimester combined screening (double/triple test):
These traditional methods are still commonly used but have lower detection rates and higher false‐positive rates compared to NIPT.

Ultrasound screening (nuchal translucency, anatomy scan):
Ultrasound remains indispensable for anatomical assessment, growth monitoring and structural anomaly detection. NIPT complements ultrasound by adding genetic information—it does not replace it.

Frequently Asked Questions

Is the NIPT test required?
No—it is completely optional and chosen by the parents and their clinician.

Can the test determine fetal sex?
Yes—if requested, fetal gender can be reliably identified after ~10 weeks.

Does NIPT replace amniocentesis?
No—NIPT is a screening test. If results are high‐risk, diagnostic testing (amniocentesis or CVS) is still required.

Do I have to fast?
No, fasting is not required prior to the blood draw.

How long to wait for results?
Typically 7–10 days; some labs offer expedited results in 3–5 days.

Is it accurate for twins?
Yes—but accuracy is slightly lower than single pregnancies; consult your doctor for twin/multiple pregnancies.

Final Thoughts

The Fetal DNA (NIPT) Test in Kadıköy offers a modern, safe, and highly accurate option for prenatal genetic screening. With minimal preparation, no risk to baby, and very early timing, it empowers expecting families to better understand their baby’s genetic health.

Choosing a trusted clinic, discussing with your obstetrician and genetic counsellor, and continuing routine prenatal care are key. While NIPT is a major advancement, it works best as part of comprehensive pregnancy care—including diet, lifestyle, ultrasound checks, and follow-up.