FETAL DNA (NIPT) TEST IN BURSA

Safe, Accurate, and Non-Invasive Prenatal Genetic Screening

What Is the NIPT Test?

NIPT (Non-Invasive Prenatal Testing) — also known as the Fetal DNA test or cell-free fetal DNA (cffDNA) test — is a modern, highly reliable method that helps detect chromosomal abnormalities in the baby through a simple blood sample from the mother. It provides early and accurate genetic information without posing any risk to either the mother or the baby.

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In Bursa, NIPT testing is offered at major hospitals, private clinics, and genetic laboratories that use advanced sequencing technologies. Because it only requires a blood sample from the mother’s arm, the procedure is completely safe — unlike invasive diagnostic tests such as amniocentesis.

How Does the NIPT Test Work?

During pregnancy, tiny fragments of the baby’s DNA, known as cell-free fetal DNA, enter the mother’s bloodstream from the placenta. From the 10th week of pregnancy, this fetal DNA can be measured and analyzed using advanced genetic sequencing techniques such as Next Generation Sequencing (NGS).

In Bursa’s specialized laboratories, these DNA fragments are carefully analyzed to detect any extra or missing chromosomes, which may indicate certain genetic disorders. The process is non-invasive, painless, and results are typically available within 7–10 days. Some laboratories also provide express results in 3–5 days for an additional fee.

What Conditions Can NIPT Detect?

Major Chromosomal Abnormalities

The NIPT test screens for the most common chromosomal conditions with high accuracy:

Down Syndrome (Trisomy 21): The most common genetic abnormality caused by an extra chromosome 21; detection rate exceeds 99%.
Edwards Syndrome (Trisomy 18): Caused by an extra chromosome 18; detection accuracy around 97%.
Patau Syndrome (Trisomy 13): Caused by an extra chromosome 13; detection accuracy above 90%.

Sex Chromosome Abnormalities

NIPT can also detect variations in sex chromosomes, including:

Turner Syndrome (45,X)
Klinefelter Syndrome (47,XXY)
Triple X Syndrome (47,XXX)
Jacobs Syndrome (47,XYY)

Extended Genetic Panels

Advanced laboratories in Bursa offer expanded NIPT panels that can identify microdeletions and microduplications such as DiGeorge, Prader-Willi, and Angelman syndromes. Your physician will help determine whether extended testing is suitable based on your family and pregnancy history.

When Should the NIPT Test Be Performed?

The NIPT test is most accurate when performed from the 10th week of pregnancy onward, when enough fetal DNA is present in the maternal bloodstream. The test can also be performed safely later in pregnancy, during the second and third trimesters, without any reduction in accuracy.

Who Should Consider the NIPT Test?

While NIPT is suitable for all pregnant women, it is particularly recommended for:

Women aged 35 years or older
Pregnancies showing abnormal first-trimester screening results
IVF or assisted reproduction pregnancies
Families with a history of chromosomal disorders
Pregnancies with ultrasound findings suggesting genetic risk
Parents wishing to avoid invasive diagnostic procedures
Carriers of balanced chromosomal translocations

Advantages of the NIPT Test

Extremely Accurate: Detects Down syndrome with over 99% accuracy.
Completely Safe: Requires only a maternal blood sample; no risk of miscarriage.
Early Testing: Can be done as early as the 10th week of pregnancy.
Determines Gender: If requested, can identify the baby’s gender with high accuracy.
Reduces Anxiety: Fewer false-positive results compared to traditional screening tests.
Convenient: Quick, painless, and does not require fasting or preparation.

Limitations of the NIPT Test

Although NIPT is a very reliable screening method, it is not a diagnostic test:

A positive (high-risk) result means there is an increased likelihood of a chromosomal abnormality but not a definite diagnosis. Confirmation through amniocentesis or chorionic villus sampling (CVS) is required.
NIPT cannot detect all genetic disorders, such as single-gene conditions or structural defects.
In rare cases, results may be inconclusive due to a low fetal DNA fraction, which is more common in early pregnancy or in women with higher BMI. Retesting after one to two weeks usually resolves this issue.
The accuracy of the test may be slightly lower for twin pregnancies compared to single pregnancies.

How Is the NIPT Test Performed?

Before the Test:
Your obstetrician or genetic counselor will explain the procedure, discuss the benefits and limitations, and help you decide which panel is most suitable.

During the Test:
A small amount of blood is drawn from your arm — no fasting or special preparation is needed. The process takes just a few minutes.

After the Test:
The sample is sent to a certified laboratory for analysis. Results are typically available within 7–10 business days, and your doctor will review them in detail with you.

Understanding the Results

Low-Risk (Negative):
Indicates a very low likelihood of the screened chromosomal abnormalities. No further testing is usually required.

High-Risk (Positive):
Indicates an increased probability of a genetic abnormality. Diagnostic tests like amniocentesis or CVS are recommended for confirmation.

Inconclusive Results:
If the sample does not contain enough fetal DNA, the test may need to be repeated. This occurs in approximately 1–2% of cases.

NIPT Test Cost in Bursa

Basic NIPT tests: 12,500 – 14,000 TL
Extended panels: 15,000 – 18,000 TL

The cost depends on the chosen panel, the laboratory, and the turnaround time. Some clinics offer express results for an additional fee.

Insurance Coverage:
The NIPT test is not covered by Turkey’s Social Security Institution (SGK). However, certain private insurance policies may cover part of the cost.

Where to Get the NIPT Test in Bursa

You can access NIPT testing in Bursa through:

Private hospitals and obstetrics clinics
Genetic diagnostic laboratories with international accreditation
University hospitals with perinatology departments

These centers work with highly trained obstetricians and geneticists to ensure accurate and reliable results.

Comparison with Other Prenatal Tests

Traditional Screening Tests (Double or Triple Test):
While still used, these tests have lower accuracy and higher false-positive rates than NIPT.

Ultrasound (Nuchal Translucency Measurement):
Ultrasound remains essential for evaluating the baby’s development. NIPT complements ultrasound but does not replace it.

Frequently Asked Questions

Is the NIPT test mandatory?
No, it’s optional and based on personal choice.

Can NIPT determine the baby’s gender?
Yes, it can determine the baby’s gender with high accuracy from week 10.

Does NIPT replace amniocentesis?
No, it’s a screening test. A high-risk result must be confirmed by diagnostic testing.

Is fasting required?
No fasting is needed before the test.

Can twins be tested?
Yes, NIPT can be used in twin pregnancies, although accuracy is slightly lower than for single pregnancies.

How long do results take?
Usually within 7–10 days; some labs offer faster results in 3–5 days.

Final Thoughts

The Fetal DNA (NIPT) Test in Bursa gives expectant parents the chance to assess their baby’s genetic health early, safely, and accurately. With advanced laboratory facilities and expert gynecologists, Bursa provides access to world-class prenatal screening.

By integrating NIPT into standard prenatal care, families gain peace of mind and valuable information without any risk to the baby. Always discuss your results with your obstetrician, continue regular ultrasound follow-ups, and maintain healthy prenatal care practices.