FETAL DNA (NIPT) TEST IN ESENYURT

Safe, Accurate, and Non-Invasive Prenatal Screening

What Is the NIPT Test?

NIPT (Non-Invasive Prenatal Testing), also known as the Fetal DNA test or cell-free fetal DNA (cffDNA) test, is a modern and safe prenatal screening method that analyzes small fragments of the baby’s DNA circulating in the mother’s bloodstream. It helps detect common chromosomal abnormalities early in pregnancy — accurately and without risk to the mother or baby.

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In Esenyurt, many private hospitals, women’s health clinics, and certified genetic laboratories perform NIPT using advanced sequencing technology. The test requires only a small blood sample from the mother’s arm and does not involve any invasive procedure, ensuring safety and comfort for expectant mothers.

How Does the NIPT Test Work?

During pregnancy, fragments of fetal DNA coming from the placenta circulate in the mother’s bloodstream. These DNA fragments, called cell-free fetal DNA (cffDNA), can be analyzed starting from the 10th week of pregnancy.

NIPT in Esenyurt is performed using Next Generation Sequencing (NGS) technology, which allows for highly precise evaluation of chromosomes. The laboratory assesses the number and structure of chromosomes to identify abnormalities, such as trisomies or sex-chromosome variations.

Results are usually available in 7–10 days, while some laboratories offer express results in as little as 3–5 days.

What Conditions Can NIPT Detect?

Major Chromosomal Abnormalities

NIPT screens for the most frequent chromosomal conditions with high accuracy:

Down Syndrome (Trisomy 21): Caused by an extra copy of chromosome 21; detection rate over 99%.
Edwards Syndrome (Trisomy 18): Caused by an extra copy of chromosome 18; detection accuracy about 97%.
Patau Syndrome (Trisomy 13): Caused by an extra copy of chromosome 13; detection accuracy above 90%.

Sex Chromosome Abnormalities

The test can also identify sex-chromosome variations such as:

Turner Syndrome (45,X)
Klinefelter Syndrome (47,XXY)
Triple X Syndrome (47,XXX)
Jacobs Syndrome (47,XYY)

Extended Genetic Panels

Some Esenyurt laboratories offer expanded NIPT panels that can detect additional rare genetic conditions, such as DiGeorge, Prader-Willi, and Angelman syndromes. Your physician can help determine whether an extended panel is appropriate for you.

When Should the NIPT Test Be Done?

The ideal time for NIPT is after the 10th week of pregnancy, when there is enough fetal DNA in the maternal blood for accurate testing. The test remains safe and reliable throughout the second and third trimesters.

Who Should Consider NIPT?

Although NIPT is suitable for all pregnant women, it is particularly recommended for:

Women aged 35 or older
Those with high-risk results from earlier screening tests
Pregnancies achieved via IVF (in vitro fertilization)
A family history of chromosomal or genetic disorders
Expectant mothers with abnormal ultrasound findings
Parents wishing to avoid invasive tests like amniocentesis
Carriers of balanced chromosomal translocations

Advantages of the NIPT Test

High Accuracy: Over 99% detection rate for Down Syndrome.
Completely Safe: Requires only a blood sample; no risk to the baby.
Early Detection: Can be performed as early as week 10.
Determines Gender: Accurately identifies the baby’s sex early in pregnancy.
Reduces Stress: Fewer false positives, reducing the need for invasive testing.
Simple and Fast: Painless blood draw, no fasting required, and quick results.

Limitations of the NIPT Test

Although NIPT is highly accurate, it is still a screening test — not a diagnostic tool.

A positive (high-risk) result does not confirm an abnormality. Diagnostic testing such as amniocentesis or CVS is required for confirmation.
NIPT does not detect all genetic diseases, such as single-gene disorders or neural tube defects.
Rarely, the test may fail to produce a result if the fetal DNA fraction is too low — more common in early pregnancies or women with higher body mass index (BMI).
The test can be performed in twin pregnancies but may have slightly reduced accuracy.

How Is the NIPT Test Performed?

Before the Test:
Your doctor or genetic counselor will explain the test procedure, what it screens for, and how results are interpreted. Many Esenyurt clinics offer genetic counseling before and after the test.

During the Test:
A small blood sample is drawn from the mother’s arm. The process takes only a few minutes and requires no fasting or special preparation.

After the Test:
The sample is analyzed in a certified laboratory. Results are typically available within 7–10 days, and your doctor will discuss the findings with you in detail.

Understanding the Results

Low-Risk (Negative):
Indicates a very low likelihood of the tested chromosomal abnormalities. Routine pregnancy care continues.

High-Risk (Positive):
Indicates increased probability of an abnormality. Diagnostic testing such as amniocentesis or CVS should be considered.

Inconclusive:
May occur if fetal DNA levels are insufficient. A repeat test after one or two weeks usually resolves the issue.

NIPT Test Cost in Esenyurt

Basic NIPT tests: 12,500 – 14,000 TL
Extended panels: 15,000 – 18,000 TL

Prices vary depending on the laboratory and the extent of testing. Some centers charge more for express results or extended analysis.

Insurance Coverage:
The NIPT test is not covered by the Turkish Social Security Institution (SGK). Some private insurance companies may reimburse part of the cost under specific conditions.

Where to Get the NIPT Test in Esenyurt

The NIPT test is available at:

Private hospitals and maternity clinics
Specialized genetic laboratories
University-affiliated hospitals with prenatal diagnostic units

All major centers in Esenyurt follow international standards, ensuring high-quality testing and accurate results.

Comparison with Other Prenatal Tests

Traditional Double and Triple Tests:
These tests are still in use but have lower detection accuracy and higher false-positive rates compared to NIPT.

Ultrasound (Nuchal Translucency):
Ultrasound remains vital for assessing fetal anatomy and development. NIPT complements ultrasound but does not replace it.

Frequently Asked Questions

Is the NIPT test mandatory?
No, it’s optional and depends on the parents’ decision.

Can the NIPT test determine the baby’s gender?
Yes, with nearly 100% accuracy from the 10th week of pregnancy.

Does NIPT replace amniocentesis?
No, NIPT is a screening tool, not a diagnostic test.

Is fasting required before testing?
No, fasting is not necessary.

Can twins be tested?
Yes, although accuracy may be slightly lower.

When will results be ready?
Generally within 7–10 days; express options may return results in 3–5 days.

Final Thoughts

The Fetal DNA (NIPT) Test in Esenyurt provides expecting families with safe, early, and accurate genetic screening without any risk to mother or baby. With advanced medical facilities and experienced specialists, Esenyurt offers reliable options for this essential prenatal test.

NIPT gives families peace of mind, enabling them to make informed choices about their pregnancy. Still, routine checkups, ultrasounds, and healthy prenatal care remain crucial for a healthy pregnancy journey.